Why the study?
Does primary hypertriglyceridaemia alter the metabolism of apoproteins AI and AII compared to normotriglyceridaemic subjects?
Population
21 subjects, comprising 11 with primary hypertriglyceridaemia and 10 normotriglyceridaemic subjects.
Comparison
Intravenous injection of autologous… vs Normotriglyceridaemic subjects.
Design
Case-control
Follow-up
14 days
Authors
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Hypertriglyceridaemia was associated with altered apo AI/AII kinetics; leaves open effects on HDL function and cardiovascular risk.
Does primary hypertriglyceridaemia alter the metabolism of apoproteins AI and AII compared to normotriglyceridaemic subjects?
Primary hypertriglyceridaemia is associated with altered metabolism of HDL apoproteins, specifically decreased synthesis of apo AI and increased catabolism of apo AII.
Rao et al. (1980) studied this question.
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