In vivo metabolism of apolipoprotein A-IV in severe hypertriglyceridemia: a combined radiotracer and stable isotope kinetic study.
Population
15 hypertriglyceridemic patients and normolipidemic controls for plasma level analysis; 2 healthy…
Comparison
Endogenous stable isotope labeling and exogenous… vs Normolipidemic controls
Design
Other
Authors
Discussion
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Member takes
Implication
Elevated apoA-IV in hypertriglyceridemia may reflect delayed catabolism; hypothesis-generating for its role as biomarker or target, no practice change yet.
Structured PICO
P
Population
15 hypertriglyceridemic patients (TG > 300 mg/dl) and normolipidemic controls for plasma level analysis; 2 healthy hypertriglyceridemic patients (mean TG = 1297 mg/dl) and normolipidemic controls for kinetic studies.
I
Intervention
Endogenous stable isotope labeling (deuterated L-leucine) and exogenous radiolabeling (125I) of apoA-IV
C
Comparator
Normolipidemic controls
O
Outcome
ApoA-IV fractional catabolic rates (FCR) and plasma levelssurrogate
Severe hypertriglyceridemia is associated with elevated plasma apoA-IV levels due to delayed catabolism rather than increased production.
Cite This Study
Vergès et al. (1994) studied this question.