Studies on the in vivo and in vitro distribution of apolipoprotein A-IV in human plasma and lymph.

In vitro incubations with human plasma and lymph, and in vivo studies in 5 human subjects (1 normolipidemic woman with chylothorax, 1 man with type 5 hyperlipoproteinemia, 1 man with mild hypertriglyceridemia, 1 man with combined hyperlipoproteinemia, 1 man with moderate hypertriglyceridemia).

Intravenous injection of 125I-labeled apo A-IV incorporated into lymph TRL, plasma TRL, HDL, or LDF (in vivo); incubation of 125I-apo A-IV with plasma or lymph (in vitro).

Redistribution of 125I-apo A-IV among triglyceride-rich lipoproteins (TRL), high density lipoprotein (HDL), and lipoprotein-deficient fraction (LDF).surrogate