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April 1, 1980Journal of Clinical InvestigationOpen Access

Human Apolipoprotein A-IV

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Population

Normal volunteers (n=14), subjects with abetalipoproteinemia (n=4), and one subject with chyluria.

Comparison

Lipid ingestion (e.g., 40 g of corn oil) vs Fasting state

Design

Other

Authors

PGPeter H.R. GreenColumbia University Irving Medical CenterRGRobert M. GlickmanNew York UniversityJRJohn W. RileyRoyal North Shore Hospital

Discussion

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Implication

Acute lipid-induced apoA-IV rise seen in volunteers; leaves open its role as marker of intestinal lipid handling or CV risk.

Structured PICO

P
Population
Normal volunteers (n=14), subjects with abetalipoproteinemia (n=4), and one subject with chyluria.
I
Intervention
Lipid ingestion (e.g., 40 g of corn oil)
C
Comparator
Fasting state
O
Outcome
Plasma apoA-IV levels and distribution in lipoproteinssurrogate

ApoA-IV is synthesized in human intestinal epithelial cells, secreted as a chylomicron and VLDL apoprotein, and its plasma levels increase following lipid ingestion.

Cite This Study

Green et al. (1980) studied this question.

synapsesocial.com/papers/6a7055a06ceb2bbd16dfdc39https://doi.org/10.1172/jci109745
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Apoprotein A-I Synthesis in Normal Intestinal Mucosa and in Tangier Disease1978 · 113 citations
  2. 2Metabolic Fate of Chylomicron Phospholipids and Apoproteins in the Rat1979 · 219 citations
  3. 3An Apolipoprotein Homolog of Rat Apolipoprotein A‐IV in Human Plasma1979 · 144 citations
  4. 4PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT1951 · 318,705 citations
  5. 5Metabolism of High-Density Lipoprotein Apolipoproteins in Tangier Disease1978 · 203 citations