Key result
Apolipoprotein A-IV knockout in mice reduced plasma triglycerides by 47% and resulted in the secretion of larger chylomicrons with delayed plasma clearance.
Why the study?
Does A-IV gene knockout alter plasma lipid levels and chylomicron metabolism in C57BL/6 mice?
Does A-IV gene knockout alter plasma lipid levels and chylomicron metabolism in C57BL/6 mice?
Effect estimate: 47% decrease
Apolipoprotein A-IV plays a previously unknown role in mediating chylomicron size and clearance, which may be important in regulating plasma lipid metabolism.
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Hypothesis-generating in mice; leaves open apolipoprotein A-IV's role in human lipid metabolism.
Kohan et al. (2011) studied Lipid metabolism. Apolipoprotein A-IV knockout vs. Wild-type mice was evaluated on Plasma triglyceride levels on chow diet (47% decrease). Apolipoprotein A-IV knockout in mice reduced plasma triglycerides by 47% and resulted in the secretion of larger chylomicrons with delayed plasma clearance.
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