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November 13, 2009Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Human Apolipoprotein A-II Determines Plasma Triglycerides by Regulating Lipoprotein Lipase Activity and High-Density Lipoprotein Proteome

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Why the study?

Does human apolipoprotein A-II regulate plasma triglycerides and lipoprotein lipase activity?

Population

Female human apoA-II-transgenic mice (hapoA-II-Tg mice) and a group of normolipidemic women

Comparison

Human apolipoprotein A-II vs Control mice

Design

Preclinical

Authors

JJJosep JulveInstituto de Salud Carlos IIIJEJoan Carles Escolá‐GilClinical Orthopaedics and Related ResearchNRNoemí RotllánInstituto de Salud Carlos III

Discussion

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Implication

ApoA-II may modulate triglyceride levels; hypothesis-generating and should not yet change practice.

Structured PICO

Does human apolipoprotein A-II regulate plasma triglycerides and lipoprotein lipase activity?

P
Population
Female human apoA-II-transgenic mice (hapoA-II-Tg mice) and a group of normolipidemic women
I
Intervention
Human apolipoprotein A-II (transgenic expression in mice, observational in humans)
C
Comparator
Control mice
O
Outcome
Triglyceride-rich lipoprotein catabolism and lipoprotein lipase (LPL) activitysurrogate

ApoA-II plays a crucial role in triglyceride catabolism by regulating lipoprotein lipase activity through modulation of the HDL proteome.

Cite This Study

Julve et al. (2009) studied this question.

synapsesocial.com/papers/6a7004ba8031ec7bb1dc1201https://doi.org/10.1161/atvbaha.109.198226
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Overexpression of Human Apolipoprotein A-II in Mice Induces Hypertriglyceridemia Due to Defective Very Low Density Lipoprotein Hydrolysis1999 · 93 citations
  2. 2Apolipoprotein AII Is a Regulator of Very Low Density Lipoprotein Metabolism and Insulin Resistance2007 · 82 citations
  3. 3Lipoprotein ApoC-II activation of lipoprotein lipase. Modulation by apolipoprotein A-IV.1990 · 301 citations
  4. 4High density lipoprotein2. Relationship of the plasma levels of this lipoprotein species to its composition, to the magnitude of postprandial lipemia, and to the activities of lipoprotein lipase and hepatic lipase.1987 · 379 citations
  5. 5Apolipoproteins C-I and C-III as important modulators of lipoprotein metabolism2001 · 294 citations