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December 27, 2007Journal of Biological ChemistryOpen Access

Apolipoprotein AII Is a Regulator of Very Low Density Lipoprotein Metabolism and Insulin Resistance

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Population

Apolipoprotein AII transgenic (apoAIItg) mice and control mice

Comparison

Rosiglitazone treatment; mouse apoAII injection vs Control mice; baseline

Design

Preclinical

Follow-up

4 hours (for injection experiment)

Authors

LCLawrence W. CastellaniCalifornia Institute of TechnologyCNCara NguyenUniversity of California, Los AngelesSCSarada CharugundlaUniversity of California, Los Angeles

Discussion

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Implication

ApoAII may regulate triglyceride-rich lipoprotein metabolism in mice; hypothesis-generating for human dyslipidemia and should not yet change practice.

Structured PICO

P
Population
Apolipoprotein AII transgenic (apoAIItg) mice and control mice
I
Intervention
Rosiglitazone treatment; mouse apoAII injection
C
Comparator
Control mice; baseline
O
Outcome
Very low density lipoprotein (VLDL) metabolism, triglyceride secretion, and hydrolysissurrogate

ApoAII regulates the metabolism of triglyceride-rich lipoproteins by transferring from HDL to VLDL, making it a poorer substrate for hydrolysis by lipoprotein lipase.

Cite This Study

Castellani et al. (2007) studied this question.

synapsesocial.com/papers/6a828d985bcab2ccdb8d5c0ahttps://doi.org/10.1074/jbc.m708995200
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Human Evidence That the Apolipoprotein A-II Gene Is Implicated in Visceral Fat Accumulation and Metabolism of Triglyceride-Rich Lipoproteins2001 · 113 citations
  2. 2Interactions of high density lipoproteins with very low and low density lipoproteins during lipolysis.1988 · 30 citations
  3. 3Interchange of Apolipoproteins between Chylomicrons and High Density Lipoproteins during Alimentary Lipemia in Man1973 · 531 citations
  4. 4Atherogenic remnant lipoproteins: role for proteoglycans in trapping, transferring, and internalizing2007 · 158 citations
  5. 5Biochemical and Genetic Association of Plasma Apolipoprotein A-II Levels With Familial Combined Hyperlipidemia2003 · 39 citations