Why the study?
Does overexpression of human apolipoprotein CII cause hypertriglyceridemia in transgenic mice?
Population
Transgenic mice expressing the human apolipoprotein CII gene under the transcriptional control of the human…
Comparison
Overexpression of human apolipoprotein CII gene… vs Control mice.
Design
Preclinical
Authors
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ApoCII overexpression induces hypertriglyceridemia in mice; leaves open its complex role in human triglyceride disorders.
Does overexpression of human apolipoprotein CII cause hypertriglyceridemia in transgenic mice?
Overexpression of human apoCII in transgenic mice causes hypertriglyceridemia due to delayed clearance of VLDL-triglyceride, suggesting a complex role for apoCII in plasma triglyceride metabolism.
Shachter et al. (1994) studied this question.
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