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April 1, 1999Journal of Biological ChemistryOpen Access

Overexpression of Human Apolipoprotein A-II in Mice Induces Hypertriglyceridemia Due to Defective Very Low Density Lipoprotein Hydrolysis

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Why the study?

Does overexpression of human apolipoprotein A-II induce hypertriglyceridemia and alter VLDL hydrolysis in mice?

Population

Transgenic mice expressing human apolipoproteinA-II at 2 and 4 times the normal concentration

Comparison

Overexpression of human apolipoprotein A-II vs Control mice

Design

Preclinical

Authors

EBElisabeth BoisferInsermGLGilles LambertInstitut National de Santé Publique du QuébecVAV. AtgerCancéropôle PACA

Discussion

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Implication

Hypothesis-generating in mice; leaves open human relevance for apoA-II in dyslipidemia and atherosclerosis.

Structured PICO

Does overexpression of human apolipoprotein A-II induce hypertriglyceridemia and alter VLDL hydrolysis in mice?

P
Population
Transgenic mice (hAIItg-delta and hAIItg-lambda) expressing human apolipoprotein (apo)A-II at 2 and 4 times the normal concentration
I
Intervention
Overexpression of human apolipoprotein A-II
C
Comparator
Control mice
O
Outcome
Lipoprotein profile (VLDL, LDL, HDL levels) and VLDL-triglyceride hydrolysis by lipoprotein lipasesurrogate

Overexpression of human apoA-II in mice induces a proatherogenic lipid profile characterized by low HDL and hypertriglyceridemia due to impaired VLDL catabolism by lipoprotein lipase.

Cite This Study

Boisfer et al. (1999) studied this question.

synapsesocial.com/papers/6a828d9a5bcab2ccdb8d5c18https://doi.org/10.1074/jbc.274.17.11564
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Premature Atherosclerosis in Patients with Familial Chylomicronemia Caused by Mutations in the Lipoprotein Lipase Gene1996 · 301 citations
  2. 2Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.1993 · 1,658 citations
  3. 3PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT1951 · 318,705 citations
  4. 4Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility1996 · 154 citations
  5. 5The properties of HDL in genetically engineered mice1994 · 36 citations