Expression of human apolipoprotein A-II in apolipoprotein E-deficient mice induces features of familial combined hyperlipidemia

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Why the study?

Does expression of human apolipoprotein A-II induce features of familial combined hyperlipidemia in apolipoprotein E-deficient mice?

Structured PICO

Does expression of human apolipoprotein A-II induce features of familial combined hyperlipidemia in apolipoprotein E-deficient mice?

Population

apolipoprotein E-deficient mice

Intervention

Expression of human apolipoprotein A-II (transgenic overexpression)

Comparator

null

Outcome

Plasma triglyceride and VLDL levelssurrogate

FCHL patients do not have plasma concentrations of human apoA-II as high as those of apoE-deficient mice overexpressing human apoA-II
the apoA-II gene has not been linked to FCHL in genome-wide scans

Authors

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ApoA-II may regulate VLDL production; hypothesis-generating for its role in human familial combined hyperlipidemia.

Escolá‐Gil et al. (2000) studied this question.

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