Key result
Parkinson's disease is associated with prolonged atrial conduction times, with P-wave dispersion (OR 1.13; 95% CI 1.02-1.25; p=0.017) identified as an independent predictor of the disease.
Why the study?
Do patients with newly diagnosed Parkinson's disease have prolonged atrial conduction times compared to healthy controls?
Case-Control (n=82)
Do patients with newly diagnosed Parkinson's disease have prolonged atrial conduction times compared to healthy controls?
Odds Ratio: 1.13 (95% CI 1.02–1.25)
p-value: p=0.017
Patients with newly diagnosed Parkinson's disease exhibit prolonged atrial conduction times, suggesting a potential increased predisposition to atrial fibrillation.
May signal atrial vulnerability in Parkinson's; leaves open whether P-wave screening predicts events or warrants trials.
Background . An increased risk of ischemic stroke has been reported in patients with Parkinson’s disease (PD). Atrial fibrillation (AF) is strongly associated with ischemic stroke. Prolonged atrial electromechanical delay (EMD) is an independent predictor for the development of AF. Aims . The aim of the present study was to evaluate the atrial conduction parameters in patients with PD and to assess their relation with the severity of PD. Study design . We prospectively enrolled 51 consecutive patients with newly diagnosed PD and 31 age- and sex-matched non-PD subjects. Methods . To assess atrial electromechanical coupling (PA), the time intervals from the onset of p wave on ECG to the late diastolic wave at the septal (PAs) and lateral (PAl) mitral annulus and lateral tricuspid annulus (PAt) were measured on Tissue Doppler Echocardiography (TDE). The difference between PAs-PAl, PAs-PAt, and PAl-PAt were defined as left intra-atrial, right intra-atrial, and interatrial EMD, respectively. P-wave dispersion (PWD) was calculated from the 12-lead ECG. Results . PWD, PAs, PAl, and PAt durations were significantly prolonged in the PD group (all p<0.001). Interatrial, right, and left intra-atrial EMD were also significantly longer in PD patients (p<0.001, p<0.001 and p=0.002, resp.). There were significant positive correlations between disease severity (UPDRS score) and PWD (r=0.34, p=0.041), left intra-atrial (r=0.39, p=0.005), and interatrial EMD (r=0.35, p=0.012). By multivariate analysis, PWD (OR: 1.13, 95% CI: 1.02–1.25; p=0.017), LA volume index (OR: 1.19, 95% CI: 1.02–1.37; p=0.021), left intra-atrial (OR: 1.12, 95% CI: 1.01–1.24; p=0.041), and interatrial EMD (OR: 1.08, 95% CI: 1.01–1.16; p=0.026) were found as independent predictors of PD. Conclusion . Atrial conduction times were longer and correlated with the severity of disease in PD patients. Prolonged inter- and intra-atrial-EMD intervals were also found as independent correlates of PD. These findings may suggest an increased predisposition to atrial fibrillation in PD.
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Çanga et al. (2018) conducted a case-control in Parkinson's disease (n=82). Parkinson's disease vs. Non-PD subjects was evaluated on P-wave dispersion (PWD) as an independent predictor of Parkinson's disease (OR 1.13, 95% CI 1.02-1.25, p=0.017). Parkinson's disease is associated with prolonged atrial conduction times, with P-wave dispersion (OR 1.13; 95% CI 1.02-1.25; p=0.017) identified as an independent predictor of the disease.
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