Key result
Erectile dysfunction linked to prolonged inter- and right intra-atrial electromechanical delay.
Why the study?
Erectile dysfunction increases the risk of atrial fibrillation, for which prolonged atrial electromechanical delay is a precursor, but electromechanical delay had not been evaluated in patients with erectile dysfunction without documented atrial fibrillation.
Does erectile dysfunction associate with prolonged atrial electromechanical delay and P-wave dispersion in patients without documented atrial fibrillation?
Case-Control (n=112)
Does erectile dysfunction associate with prolonged atrial electromechanical delay and P-wave dispersion in patients without documented atrial fibrillation?
p-value: p=<0.001
Erectile dysfunction is associated with prolonged atrial electromechanical delay and P-wave dispersion, suggesting it may serve as a marker for increased risk of future atrial fibrillation development.
Background: It is well known that erectile dysfunction (ED) is associated with increased risk of atrial fibrillation (AF) development. On the other hand, prolongation of the duration of atrial electromechanical delay (AEMD) is known to be a precursor for AF development. We aimed to evaluate AEMD in patients with ED patients without documented AF.Methods: Total of 68 outpatients with previously documented vascular ED and 44 participants without ED were enrolled to the current study. Sixty-eight patients with ED called as ED group and 44 participants without ED served as control group. We performed International Index of Erectile Function (IIEF-5) questionnaire for all participants to determine the disease severity of ED groups and to diagnose ED in control groups. Patients with a IIEF-5 score ≥22 were defined as having normal erectile functions. Both intra- and inter-AEMD were measured with tissue Doppler imaging. P-wave dispersion (PWD) was measured on a 12-lead electrocardiogram.Results: Basal characteristics were similar between the two groups. PWD, inter- and right intra-AEMD were significantly prolonged in patients with ED, compared to the control group (p = .02, p < .001 and p < .001, respectively). In the correlation analysis, IIEF-5 score was significantly negative correlated with systolic blood pressure, right intra- and inter-AEMD (r = –0.37, p = .02; r= −0.27, p = .02; r = –0.39, p = .001, respectively).Conclusions: According to current study results, AEMD is significantly correlated with ED severity and may be useful to stratify ED patients to the high-risk group for future development of AF as a cheap and easy method.
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Altunkol et al. (2019) conducted a case-control in Erectile dysfunction without documented atrial fibrillation (n=112). Erectile dysfunction vs. Participants without erectile dysfunction (IIEF-5 score ≥22) was evaluated on Inter- and right intra-atrial electromechanical delay (AEMD) and P-wave dispersion (p=<0.001). Erectile dysfunction was associated with significantly prolonged inter- and right intra-atrial electromechanical delay compared to controls without the condition (p<0.001).
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