Key result
Irregular dietary vitamin K intake impairs VKA efficacy through unstable INR control.
Why the study?
Dietary vitamin K intake directly influences the efficacy of vitamin K antagonists, motivating a summary of vitamin K's role in coagulation and its impact on VKA therapy.
Does dietary vitamin K intake affect the anticoagulant efficacy of Vitamin K Antagonists in patients receiving VKA therapy?
Does dietary vitamin K intake affect the anticoagulant efficacy of Vitamin K Antagonists in patients receiving VKA therapy?
Effective anticoagulation with VKAs requires personalized dosage, regular INR monitoring, and conscious management of dietary vitamin K intake to prevent INR fluctuations.
May support vitamin K education for VKA stability; leaves open need for prospective outcome trials.
Background: The vitamin K antagonists’ (VKA) mechanism of action is closely related to the metabolic pathways of vitamin K. Dietary vitamin K intake can directly translate into efficacy of VKA therapy. Aim: The aim of the study was to summarize information about the role of vitamin K in the coagulation process and its impact on Vitamin K Antagonists. Material and methods: A non-systematic litrerature review was conducted using databases such as Pubmed and Cochrane Database. Search terms included VKA pharmacokinetics, INR targets and dietary management strategies. Results: Irregular intake of vitamin K negatively affects the action of hydroxycoumarin derivatives by causing INR fluctuations and subtherapeutic anticoagulation. Excessive doses of vitamin K reduce VKA activity and increase risk of side effects such as thromboembolic complications. Conclusions: Effective anticoagulation with VKAs requires personalized dosage, regular INR monitoring and conscious management of vitamin K intake.
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Bukała et al. (2026) conducted a review in Patients receiving Vitamin K Antagonists. Dietary Vitamin K intake was evaluated. Irregular dietary vitamin K intake negatively affects the efficacy of vitamin K antagonists by causing INR fluctuations and subtherapeutic anticoagulation.
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