Key result
VKA reversal strategies require tailoring to patient bleeding status and clinical urgency.
Population
Patients treated with Vitamin K antagonists who require reversal due to bleeding, supratherapeutic INR, or…
Design
Review
Authors
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Tailoring VKA reversal to bleeding status and urgency guides decisions now; confirms established strategies but leaves open prospective validation.
This review summarizes the established strategies for reversing vitamin K antagonists in clinical practice based on patient bleeding status and procedural urgency.
Sabine Eichinger (2016) conducted a review in Thrombotic disorders requiring vitamin K antagonist reversal. Vitamin K antagonist reversal strategies (withholding VKA, vitamin K1, procoagulant factors) was evaluated. Reversal strategies for vitamin K antagonists, including withholding the drug, administering vitamin K1, and substituting procoagulant factors, must be tailored to patient bleeding status and urgency.
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