Angiotensin (1-7) exhibits biphasic vascular effects in rat aorta, suggesting it acts as a modulator within the renin-angiotensin system.
Answers are grounded in this paper and cite their sources.
Ang (1-7) biphasic effects in rat aorta support its role as RAS modulator; leaves open translational relevance for human vascular therapies.
Using isolated rat aortic rings perfused with Krebs-Henseleit saline, the vascular effects of angiotensin (1-7) (Ang [1-7]) and its interactions with angiotensin II (Ang II) were investigated. Ang (1-7) induced endothelium-dependent relaxation and vasodilating effects in preparations precontracted with phenylephrine. Without preconstriction, Ang (1-7) at high doses (10(-6) 10(-5) M) produced either a significant inhibition of Ang II-induced vasoconstriction or a non-tachyphylactic vasopressor response. While losartan inhibited the vasoconstriction induced by Ang (1-7), A779 blocked only its relaxation. Unlike losartan, blockade of AT(2)-receptors with PD 123319 had no effect. Taking into account the biphasic effects of angiotensin (1-7), we propose that it is one of the active components of the renin-angiotensin system, which is involved as a modulator both in the counter-regulatory actions of Ang II and in the self-regulation of its own vasodilating effects.
No takes yet. Share an insight, caveat, or question.
Hâulică et al. (2003) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: