Population
Isolated segments of rat caudal artery and rat vas deferens preparations
Comparison
Losartan and PD 123319 vs Angiotensin II alone
Design
Preclinical
Authors
Loading...
Animal findings on differential AT receptor roles in vasoconstriction versus sympathetic transmission remain hypothesis-generating; human confirmation needed before any therapeutic extrapolation.
The enhancement of sympathetic neuroeffector transmission by angiotensin II involves receptor subtypes sensitive to both losartan and PD 123319, whereas direct vasoconstriction involves only a losartan-sensitive subtype.
Cox et al. (1995) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: