Population
Isolated caudal arteries of spontaneously hypertensive (SH) and age-matched normotensive (Wistar-Kyoto) rats
Comparison
Angiotensin II alone or in combination with… vs Baseline responses and comparison between SH and…
Design
Preclinical
Authors
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AT1 mediation of Ang II vasoconstriction holds in rat arteries; hypothesis-generating and leaves open human translation.
In isolated caudal arteries of spontaneously hypertensive and normotensive rats, angiotensin II enhances noradrenergic transmission primarily via AT1 receptors, with strain-specific synergistic interactions observed with receptor antagonists.
Cox et al. (1996) studied this question.
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