Why the study?
Does high-dosage candesartan reduce the progression of renal injury in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR) that underwent unilateral nephrectomy beginning 8 weeks after birth
Comparison
Candesartan at standard 5 mg/kg per d, high 25… vs Vehicle (control)
Design
Preclinical
Follow-up
14 months
Authors
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Hypothesis-generating for ultrahigh-dose candesartan in hypertensive CKD; prospective human trials required before clinical use.
Does high-dosage candesartan reduce the progression of renal injury in spontaneously hypertensive rats?
Ultrahigh-dose candesartan provides dose-dependent, anti-inflammatory renal protection in a rat model of chronic kidney disease, mediated by suppression of NF-kappaB activation and chemokine expression.
Yu et al. (2007) studied this question.
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