Why the study?
Is serum C-reactive protein concentration elevated in patients with heart failure?
Is serum C-reactive protein concentration elevated in patients with heart failure?
Heart failure is associated with elevated serum C-reactive protein concentrations, which correlate with disease severity.
Elevated CRP associates with HF severity in this cohort; extends observational links to inflammation but should not yet change practice.
The serum concentration of C-reactive protein was prospectively assessed in 37 patients with various degrees of heart failure. The serum concentration of C-reactive protein was higher than normal in 26 (70%) patients. The concentration was directly related to the severity of heart failure and the stage of decompensation. Hepatic cell damage is the most likely stimulus to cytokine production and hence release of C-reactive protein in heart failure. Heart failure is an additional cause of raised serum concentration of C-reactive protein but the pathological importance of this feature is not yet known.
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Pye et al. (1990) studied this question.
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