Why the study?
Does OG-VI infusion improve myocardial mechanical function and energy metabolism in a dog model of stunned myocardium?
Population
Pentobarbital-anesthetized dogs subjected to 20 min ligation of the left anterior descending coronary…
Comparison
OG-VI infused at 0.1 or 0.2 ml/kg/min from the… vs Saline infusion
Design
Preclinical
Follow-up
30 minutes (reperfusion phase)
Authors
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Enhances recovery in canine stunned myocardium; leaves open translation to human ischemia-reperfusion injury.
Does OG-VI infusion improve myocardial mechanical function and energy metabolism in a dog model of stunned myocardium?
OG-VI infusion demonstrates cardioprotective effects and positive inotropic action in a canine model of ischemia-reperfusion injury by restoring tissue ATP levels.
Satoh et al. (1993) studied this question.
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