February 1, 2000Coronary Artery Disease

Effects of pimobendan and EGIS 9377, cardiotonic agents, and OG-VI, a nucleoside–nucleotide mixture, administered during reperfusion after ischemia on stunned myocardium in dogs

View Full Paper

Ask AI

Bookmark

Why the study?

Does administration of pimobendan, EGIS 9377, or OG-VI improve the condition of stunned myocardium in dogs after ischemia and reperfusion?

Population

Dogs anesthetized with pentobarbital subjected to 20 min ligation of left anterior descending coronary…

Comparison

Pimobendan, EGIS 9377, or OG-VI, administered 30… vs Corresponding vehicle or saline solution

Design

Preclinical

Follow-up

60 min reperfusion

Authors

TFTakashi FukutomiTokyo Institute of Technology KSKumi SatohHokkaido University of Science SOShohei OgoshiKochi Medical School Hospital

Discussion

Member takes

Implication

Supports testing these agents for myocardial stunning; leaves open translation from canine models to clinical reperfusion injury.

Structured PICO

Does administration of pimobendan, EGIS 9377, or OG-VI improve the condition of stunned myocardium in dogs after ischemia and reperfusion?

Population

Dogs anesthetized with pentobarbital subjected to 20 min ligation of left anterior descending coronary artery and then 60 min reperfusion

Intervention

Pimobendan (0.3 and 1 mg/kg IV), EGIS 9377 (1 and 3 mg/kg IV), or OG-VI (1.2 mumol/kg per min infusion for 30 min), administered 30 min after the onset of reperfusion

Comparator

Corresponding vehicle or saline solution

Outcome

Shortening of myocardial segment measured by sonomicrometrysurrogate

Administration of cardiotonic agents (pimobendan, EGIS 9377) and a nucleoside-nucleotide mixture (OG-VI) during reperfusion ameliorates myocardial stunning without worsening energy balance in a canine model.

Cite This Study

Fukutomi et al. (2000) studied this question.

synapsesocial.com/papers/6a8516a026ef723ab5be0089 https://doi.org/10.1097/00019501-200002000-00014

View Full Paper

Ask AI

Bookmark

Effects of pimobendan and EGIS 9377, cardiotonic agents, and OG-VI, a nucleoside–nucleotide mixture, administered during reperfusion after ischemia on stunned myocardium in dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of pimobendan and EGIS 9377, cardiotonic agents, and OG-VI, a nucleoside–nucleotide mixture, administered during reperfusion after ischemia on stunned myocardium in dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider