Key result
Combination therapy with two or more agents having complementary mechanisms of action is the most effective method for achieving strict blood pressure goals in high-risk patients.
Why the study?
Does fixed-dose combination therapy improve the achievement of lower blood pressure goals in high-risk patients?
Does fixed-dose combination therapy improve the achievement of lower blood pressure goals in high-risk patients?
Fixed-dose combination therapy is highlighted as an effective strategy to achieve lower blood pressure targets, potentially reducing cardiovascular and renal risks that begin at thresholds as low as 115/75 mm Hg.
Answers are grounded in this paper and cite their sources.
Supports complementary combination therapy for strict BP goals in high-risk patients; leaves open prospective validation of fixed-dose regimens.
Expert committees in the United States and Europe formulated their currently recommended target blood pressures of <140/90 mm Hg or <130/80 mm Hg in persons with diabetes, chronic kidney disease, or coronary artery disease based on the totality of clinical data available at the time. However, accumulating evidence indicates that increased risk for cardiovascular and renal complications of hypertension may begin at a threshold of 115/75 mm Hg, suggesting that benefit from treatment may occur when blood pressure targets are lower than those currently recommended. Combination therapy with two or more agents having complementary mechanisms of action is the most effective method for achieving strict blood pressure goals in high-risk patients. Several clinical trials are under way to further determine the risks and benefits of lowering blood pressure beyond the currently recommended threshold.
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Jan Basile (2008) conducted a review in Hypertension. Fixed-dose combination therapy was evaluated. Combination therapy with two or more agents having complementary mechanisms of action is the most effective method for achieving strict blood pressure goals in high-risk patients.
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