Key result
Isolated systolic hypertension in 6 cerebral aneurysm models produced greater adverse hemodynamic changes (TAWSS, OSI, RRT) than normotensive and higher hypertension conditions.
Why the study?
Hemodynamics is relevant to cerebral aneurysm development and rupture, making the study of different human physiological conditions important for understanding pathology and rupture risk.
Does isolated systolic hypertension cause more adverse hemodynamic changes in cerebral aneurysm models compared to normotensive or higher hypertensive conditions?
Does isolated systolic hypertension cause more adverse hemodynamic changes in cerebral aneurysm models compared to normotensive or higher hypertensive conditions?
Isolated systolic hypertension may induce more adverse hemodynamic changes in cerebral aneurysms than sustained higher hypertension, potentially increasing the risk of arterial wall remodeling and rupture.
Answers are grounded in this paper and cite their sources.
ISH effects on aneurysm hemodynamics remain preliminary; hypothesis-generating and leaves open clinical translation to rupture risk.
Hemodynamics is recognized as a relevant factor in the development and rupture of cerebral aneurysms, so further studies related to different physiological conditions in human represent an advance in understanding the pathology and rupture risk. In this paper, Fluid-structure interaction simulations (FSI) were carried out in six models of cerebral aneurysms, in order to study the hemodynamics effects of an isolated systolic hypertension (ISH) condition and compare it to a normal or normotensive pressure condition and a higher hypertension condition. Interestingly, the ISH condition showed, in general, the greatest hemodynamics changes, evidenced in the Time-Averaged Wall Shear Stress (TAWSS), Oscillatory Shear Index (OSI), and Relative Residence Time (RRT) parameters, with respect to a normal condition. These results could imply that a not high-pressure condition (ISH), characterized with a different shape and an abrupt change in its diastolic and systolic range may present more adverse hemodynamic changes compared to a higher-pressure condition (such as a hypertensive condition) and therefore have a greater incidence on the arterial wall remodeling and rupture risk.
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Barahona et al. (2021) studied Cerebral aneurysms (n=6). Isolated systolic hypertension (ISH) condition vs. Normal/normotensive pressure and higher hypertension conditions was evaluated on Hemodynamics changes (TAWSS, OSI, and RRT parameters). Isolated systolic hypertension in 6 cerebral aneurysm models produced greater adverse hemodynamic changes (TAWSS, OSI, RRT) than normotensive and higher hypertension conditions.
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