Key result
The E314 antibody at 300 nM significantly inhibited human Kv1.3 current densities by 94% in HEK 293 cells and 90% in Jurkat T cells without affecting other closely related potassium or cardiac ion channels.
Why the study?
Does the E314 antibody specifically inhibit human Kv1.3 channels without affecting other cardiac and neuronal ion channels?
Does the E314 antibody specifically inhibit human Kv1.3 channels without affecting other cardiac and neuronal ion channels?
p-value: p=<0.001
The E314 antibody is a potent and specific blocker of the human Kv1.3 channel, showing promise as a targeted immunosuppressant without off-target cardiac electrophysiological effects.
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E314 may enable selective Kv1.3 targeting for immunosuppression; leaves open in vivo efficacy and clinical translation.
Yang et al. (2012) studied None (healthy/baseline cells) (n=11). E314 antibody vs. Control (absence of antibody) was evaluated on Inhibition of hKv1.3 current densities at +50 mV (p=<0.001). The E314 antibody at 300 nM significantly inhibited human Kv1.3 current densities by 94% in HEK 293 cells and 90% in Jurkat T cells without affecting other closely related potassium or cardiac ion channels.