Key result
Zhigancao Decoction combined with anti-arrhythmic drugs significantly improved total effects for premature ventricular contractions compared to anti-arrhythmic drugs alone (RR 1.30; 95% CI 1.22-1.38).
Why the study?
Does Zhigancao Decoction improve total effects and reduce ventricular premature beats in patients with premature ventricular contractions?
Population
2441 patients with premature ventricular contractions (PVCs) from 25 randomized clinical trials
Comparison
Zhigancao Decoction alone or combined with… vs Anti-arrhythmic drugs alone
Design
Meta-analysis
Authors
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May support adjunctive use for PVCs; leaves open confirmation in high-quality RCTs.
Systematic Review (n=2,441)
Does Zhigancao Decoction improve total effects and reduce ventricular premature beats in patients with premature ventricular contractions?
Relative Risk: 1.3 (95% CI 1.22–1.38)
p-value: p=<0.00001
Zhigancao Decoction, alone or as an adjunct to anti-arrhythmic drugs, may reduce premature ventricular contractions, though evidence is limited by low methodological quality.
Liu et al. (2015) conducted a systematic review in Premature ventricular contractions (PVCs) (n=2,441). Zhigancao (ZGC) Decoction combined with anti-arrhythmic drugs vs. Anti-arrhythmic drugs alone was evaluated on Improving total effects (RR 1.30, 95% CI 1.22-1.38, p=<0.00001). Zhigancao Decoction combined with anti-arrhythmic drugs significantly improved total effects for premature ventricular contractions compared to anti-arrhythmic drugs alone (RR 1.30; 95% CI 1.22-1.38).
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