Key result
Zhigancao decoction increases total effective rate ~19% vs standard therapy in heart failure with depression.
Why the study?
Chronic heart failure combined with depression presents a clinical challenge because physical and psychological symptoms mutually exacerbate each other.
Does Zhigancao decoction added to conventional therapy improve clinical efficacy, cardiac function, and depressive symptoms in patients with chronic heart failure combined with depression?
Population
122 patients with CHF and depression
Comparison
Zhigancao decoction plus conventional therapy vs standard Western treatment
Authors
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Supports adjunctive Zhigancao decoction in chronic heart failure with depression; extends randomized evidence for traditional Chinese medicine integration.
RCT (n=122)
Random number table method
No
Does Zhigancao decoction added to conventional therapy improve clinical efficacy, cardiac function, and depressive symptoms in patients with chronic heart failure combined with depression?
Absolute Event Rate: 95.16% vs 80%
p-value: p=<0.05
Zhigancao decoction as an adjunct to conventional Western medicine significantly improved clinical efficacy, cardiac function, and depressive symptoms in patients with chronic heart failure and depression.
Wang et al. (2025) conducted an RCT in Chronic heart failure combined with depression (n=122). Zhigancao decoction plus conventional Western medicine vs. Conventional Western medicine was evaluated on Total effective rate (p=<0.05). Zhigancao decoction combined with conventional Western medicine significantly increased the total effective rate to 95.16% compared to 80.00% with conventional therapy alone in patients with chronic heart failure and depression.
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