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May 18, 2021MedicineOpen Access

Efficacy and safety of Linggui Zhugan decoction in the treatment of chronic heart failure with Yang deficiency

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Why the study?

Guidelines suggest traditional Chinese medicine as an adjunct in chronic heart failure, but more convincing clinical evidence is needed for therapies like Linggui Zhugan decoction.

Does Linggui Zhugan decoction improve NT-proBNP and LVEF in adults with chronic heart failure and Yang deficiency?

Population

Patients with chronic heart failure and Yang deficiency

Comparison

Linggui Zhugan decoction vs comparator not specified

Design

Systematic review and meta-analysis protocol of randomized controlled trials

Authors

YLYumeng LiHWHuaqin WuBZBingxuan Zhang

Discussion

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Overview

Supports adjunct LGZGD for Yang-deficient CHF; extends RCT evidence for TCM integration in guidelines.

Structured PICO

Does Linggui Zhugan decoction improve NT-proBNP and LVEF in adults with chronic heart failure and Yang deficiency?

P
Population
Adults (18 years or older) with chronic heart failure (CHF) of any ejection fraction type, meeting the description of Yang deficiency syndrome in traditional Chinese medicine.
I
Intervention
Linggui Zhugan decoction (LGZGD) combined with conventional medical treatment (meeting 2016 ESC guidelines) for at least two weeks.
C
Comparator
Conventional medical treatment alone or combined with placebo for at least two weeks.
O
Outcome
n-terminal brain natriuretic peptide (NT-proBNP) and left ventricular ejection fraction (LVEF)surrogate

This protocol outlines a planned systematic review and meta-analysis to evaluate the efficacy and safety of Linggui Zhugan decoction as an adjunct therapy for chronic heart failure with Yang deficiency.

Cite This Study

Li et al. (2021) studied this question.

synapsesocial.com/papers/6a70a290f44fa9f079de5032https://doi.org/10.1097/md.0000000000026012
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