December 20, 2007Expert Review of Cardiovascular Therapy
The need for wider and appropriate utilization of aspirin and statins in the treatment and prevention of cardiovascular disease
Key result
The combination of aspirin and statins conferred greater clinical benefits than either agent alone on myocardial infarction, occlusive stroke, and cardiovascular death.
Why the study?
Does the combination of aspirin and statins reduce cardiovascular events in patients at risk for or with cardiovascular disease?
Population
Patients at risk for or with cardiovascular disease (primary and secondary prevention)
Comparison
Aspirin and statins vs Either agent alone or no treatment
Design
Review
Authors
Discussion
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Implication
May support combined aspirin-statin therapy for CV risk reduction; leaves open confirmation in prospective trials.
Structured PICO
Does the combination of aspirin and statins reduce cardiovascular events in patients at risk for or with cardiovascular disease?
P
Population
Review of evidence including a meta-analysis of 90,056 subjects treated for 5 years, evaluating the use of aspirin and statins for the prevention of cardiovascular disease.
I
Intervention
Aspirin and statins
C
Comparator
Either agent alone or no treatment
O
Outcome
Myocardial infarction, stroke, cardiovascular death, and total mortalityhard clinical
Wider and more appropriate use of aspirin and statins, particularly in combination, can significantly reduce premature MI, stroke, and cardiovascular death.
Limitations
- Data on stroke and cardiovascular death for aspirin in primary prevention remain inconclusive.
Cite This Study
Hennekens et al. (2007) conducted a review in Cardiovascular disease (n=90,056). Aspirin and statins vs. Either agent alone or placebo was evaluated on Myocardial infarction, stroke, cardiovascular death, and total mortality. The combination of aspirin and statins conferred greater clinical benefits than either agent alone on myocardial infarction, occlusive stroke, and cardiovascular death.