Key result
Cardiac-specific overexpression of Hsp20 significantly increased myocardial capillary density compared to wild-type hearts, functioning as a novel cardiokine to promote angiogenesis via VEGFR2.
Why the study?
Does extracellular Hsp20 promote angiogenesis in endothelial cells and mouse hearts?
Does extracellular Hsp20 promote angiogenesis in endothelial cells and mouse hearts?
Absolute Event Rate: 122% vs 25%
p-value: p=<0.05
Extracellular Hsp20 functions as a novel cardiokine that promotes myocardial angiogenesis through direct interaction with VEGFR2.
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Animal data only; hypothesis-generating for Hsp20 as a cardiokine target in human myocardial angiogenesis.
Zhang et al. (2012) studied Myocardial ischemia/reperfusion and angiogenesis. Hsp20 overexpression and recombinant Hsp20 protein vs. Wild-type mice, BSA control, or Ad.GFP was evaluated on Cardiac capillary density (vessels/mm2) (p=<0.05). Cardiac-specific overexpression of Hsp20 significantly increased myocardial capillary density compared to wild-type hearts, functioning as a novel cardiokine to promote angiogenesis via VEGFR2.
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