Key result
Antiarrhythmic drugs targeting specific cardiac potassium channels have seen limited developmental progress due to an incomplete understanding of complex physiological ionic interactions.
Design
Review
Authors
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Limited antiarrhythmic progress warrants caution in novel pursuits; leaves open integrated ion channel modeling as a research priority.
This review highlights the physiological roles of cardiac potassium channels and the challenges in developing temporally and spatially selective antiarrhythmic drugs targeting them.
Jeevaratnam et al. (2017) conducted a review in Cardiac arrhythmias. Antiarrhythmic drugs targeting cardiac potassium channels was evaluated. Antiarrhythmic drugs targeting specific cardiac potassium channels have seen limited developmental progress due to an incomplete understanding of complex physiological ionic interactions.
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