Novel Therapies for Osteoarthritis Treatment: An Overview of Recent Developments

Background and Aim: Current treatment options can be effective in reducing pain and improving function, but they do not address the disease process of Osteoarthritis (OA).Hence, there is a pressing need for novel therapies that can modify the disease process and slow or halt the progression of OA.We aimed to analyze and synthesize the information from the selected articles to provide an in-depth and comprehensive overview of the latest developments in the field of osteoarthritis treatment. Purpose and Methods:We conducted a thorough literature search using relevant keywords such as "Osteoarthritis," "DMOADS," "novel therapies," "regenerative medicine," and "IADDS" on databases including Pubmed, Scopus, and Google Scholar.Our search involved a review of a significant number of peer-reviewed articles, ensuring that the information we gathered was reliable and up to date.To create a summary that truly reflects the current state of knowledge in the field of osteoarthritis treatment, we investigated and compiled the data from the most relevant articles. Conclusion:Novel therapies, such as DMOADs, gene therapy, and regenerative medicine, are being investigated to modify disease progression.Biomechanical factors are critical in the development of OA, and therapies targeting abnormal joint loading and kinematics are emerging.Furthermore, intra-articular drug delivery systems (IADDS) have emerged as a promising strategy for the targeted and sustained delivery of drugs to the affected joint.Further research is needed to optimize these treatments, and clinical trials have shown moderate evidence of their efficacy.The variability of the illness, the absence of reliable biomarkers, and the requirement for suitable animal models are all challenges.Despite these challenges, the development of novel therapies offers hope for patients with OA.