What question did this study set out to answer?

To investigate the molecular mechanisms by which mechanical stress and WISP-1 drive fibrosis and hypertrophy of the ligamentum flavum.

June 1, 2021Experimental & Molecular MedicineOpen Access

WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling

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Authors

CSChao SunHebei Medical University QMQinghong MaNanjing Jiangning Hospital JYJian YinNanjing Jiangning Hospital

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Implication

Experimental study reveals that mechanical stress induces ligamentum flavum fibrosis through WISP-1 and Hedgehog-Gli1 signaling in rabbits, highlighting Hedgehog as a potential therapeutic target.

Key Points

To investigate the molecular mechanisms by which mechanical stress and WISP-1 drive fibrosis and hypertrophy of the ligamentum flavum.
Analyzed Gli1 expression in human hypertrophic ligamentum flavum tissue and evaluated the effects of mechanical stretch, recombinant WISP-1, and the Hedgehog inhibitor cyclopamine in cultured fibroblasts.
Established a mechanical stress-induced rabbit model of ligamentum flavum hypertrophy to assess the in vivo therapeutic efficacy of cyclopamine on fibrotic remodeling.
Mechanical stretching upregulated WISP-1, which triggered fibrogenesis and induced fibroblast-to-myofibroblast differentiation through activation of the Hedgehog-Gli1 pathway.
Cyclopamine administration attenuated WISP-1-induced fibrogenesis in vitro and significantly suppressed collagen expression, fibroblast proliferation, α-SMA levels, and tissue hypertrophy in the rabbit model.

Cite This Study

Sun et al. (2021) studied this question.

synapsesocial.com/papers/6a74f65633d16877c7f55896 https://doi.org/10.1038/s12276-021-00636-5

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Implication

Experimental study reveals that mechanical stress induces ligamentum flavum fibrosis through WISP-1 and Hedgehog-Gli1 signaling in rabbits, highlighting Hedgehog as a potential therapeutic target.

WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling

Discussion

Member takes

Implication

Key Points

Cite This Study

WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling

Discussion

Member takes

Implication

Key Points

Cite This Study

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