Key result
Angptl2 expression is significantly increased in hypertrophied ligamentum flavum tissue from patients with lumbar spinal canal stenosis and positively correlates with tissue thickness (R=0.60, P<0.01).
Population
58 ligamentum flavum samples from 31 patients undergoing lumbar surgery, comprising an LSCS group and a…
Comparison
In vitro mechanical stretching stress… vs Non-LSCS LF tissue, unstretched cells, and…
Design
Preclinical
Authors
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Angptl2 may promote ligamentum flavum hypertrophy; hypothesis-generating for targeted inhibition in spinal stenosis.
Observational (n=31)
Yes
Effect estimate: R = 0.60
p-value: p=<0.01
Mechanical stress induces Angptl2 expression in ligamentum flavum fibroblasts, which promotes tissue degeneration and hypertrophy via TGF-β1/Smad signaling in lumbar spinal canal stenosis.
Nakamura et al. (2014) conducted an observational in Lumbar Spinal Canal Stenosis (n=31). Lumbar spinal canal stenosis (hypertrophied ligamentum flavum) vs. Non-LSCS lumbar diseases was evaluated on Correlation between Angptl2 mRNA expression and ligamentum flavum thickness (R = 0.60, p=<0.01). Angptl2 expression is significantly increased in hypertrophied ligamentum flavum tissue from patients with lumbar spinal canal stenosis and positively correlates with tissue thickness (R=0.60, P<0.01).
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