What question did this study set out to answer?

To describe key considerations, knowledge gaps, and research priorities regarding etiologic screening and targeted treatment for chlamydia, gonorrhea, and trichomoniasis during pregnancy to inform global clinical guidelines.

August 10, 2020Sexually Transmitted DiseasesOpen Access

Sexually Transmitted Infections in Pregnancy: A Narrative Review of the Global Research Gaps, Challenges, and Opportunities

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Authors

JGJuliana GrantWashington State Department of Health RCR Matthew ChicoUniversity of London ALAnne CC LeeBrigham and Women's Hospital

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Implication

Narrative review identifies critical evidence gaps in etiologic prenatal STI screening, highlighting the need for targeted trials to guide global maternal-child health recommendations.

Key Points

To describe key considerations, knowledge gaps, and research priorities regarding etiologic screening and targeted treatment for chlamydia, gonorrhea, and trichomoniasis during pregnancy to inform global clinical guidelines.
Conducted a narrative review of literature from PubMed and clinical trials registries searched through January 20, 2020, alongside clinical guidelines and expert input.
Synthesized findings using World Health Organization guideline development frameworks tailored to low- and middle-income countries.
Identified zero completed randomized controlled trials evaluating etiologic screening paired with targeted antimicrobial treatment in pregnancy.
Determined that standard syndromic management has poor diagnostic accuracy leading to overtreatment and undertreatment, while evidence on presumptive treatment remains mixed.
Observed that cost-effectiveness depends heavily on regional disease prevalence and access to high-accuracy, low-cost diagnostic tests, despite preliminary data showing high patient acceptability.

Cite This Study

Grant et al. (2020) studied this question.

synapsesocial.com/papers/6a74f97a96d04a2f43f56b31 https://doi.org/10.1097/olq.0000000000001258

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Implication

Narrative review identifies critical evidence gaps in etiologic prenatal STI screening, highlighting the need for targeted trials to guide global maternal-child health recommendations.

Sexually Transmitted Infections in Pregnancy: A Narrative Review of the Global Research Gaps, Challenges, and Opportunities

Discussion

Member takes

Implication

Key Points

Cite This Study

Sexually Transmitted Infections in Pregnancy: A Narrative Review of the Global Research Gaps, Challenges, and Opportunities

Discussion

Member takes

Implication

Key Points

Cite This Study

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