Key result
QuickOpt optimization of AV and VV delays (n=20) was significantly faster than echocardiography (n=24) and yielded similar improvements in cardiac function and LVEF at 12 months.
Why the study?
Does intracardiac electrography (QuickOpt) improve haemodynamic and clinical outcomes compared to echocardiography for AV/VV delay optimization in patients with CRT devices?
Cohort (n=44)
Does intracardiac electrography (QuickOpt) improve haemodynamic and clinical outcomes compared to echocardiography for AV/VV delay optimization in patients with CRT devices?
Intracardiac electrography (QuickOpt) is a faster alternative to echocardiography for CRT optimization, yielding similar long-term improvements in cardiac function and exercise capacity.
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May support faster CRT optimization without functional loss; leaves open confirmation in randomized trials before practice change.
OBJECTIVES: To compare the haemodynamic results and long-term clinical outcomes of intracardiac electrography (QuickOpt®; St Jude Medical, St Paul, MN, USA) and echocardiography for optimization of atrioventricular (AV) and interventricular (VV) delays in cardiac resynchronization therapy (CRT). METHODS: Patients with CRT devices were prospectively enrolled; AV/VV delays were optimized by either QuickOpt® or echocardiography. Patients in the QuickOpt® group underwent both echocardiography and QuickOpt® optimization, and QuickOpt® AV/VV delays were used to program the CRT. All patients were followed-up for 12 months. RESULTS: In total, 44 patients were enrolled. There was good correlation between AV/VV delays determined by QuickOpt® (n = 20) and echocardiography (n = 24). QuickOpt® was significantly faster than echocardiography-guided optimization. Cardiac function, 6-min walking distance and left ventricular ejection fraction were significantly and similarly improved in both groups at 6 and 12 months compared with baseline. In the QuickOpt® group, left ventricular end diastolic diameters were significantly smaller at 6 and 12 months compared with baseline. CONCLUSIONS: QuickOpt® is a quick, convenient and easy to perform method for optimization of AV and VV delays, with a similar long-term clinical outcome to echocardiography-guided optimization.
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Wang et al. (2013) conducted a cohort in Heart failure (n=44). Intracardiac electrography (QuickOpt) optimization vs. Echocardiography-guided optimization was evaluated on Haemodynamic results and long-term clinical outcomes (cardiac function, 6-min walking distance, left ventricular ejection fraction). QuickOpt optimization of AV and VV delays (n=20) was significantly faster than echocardiography (n=24) and yielded similar improvements in cardiac function and LVEF at 12 months.
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