Key result
Individuals with higher fasting blood glucose (>90.5 mg/dL) demonstrated significantly lower heart rate variability indices, including SDNN (56.1 vs 62.5 ms), both at fasting and after carbohydrate overload.
Why the study?
It was unknown whether blood glucose levels influence cardiac autonomic modulation during fasting and after carbohydrate overload conditions.
Does higher fasting blood glucose and carbohydrate overload impair cardiac autonomic modulation in healthy adults?
Cross-Sectional (n=108)
No
Does higher fasting blood glucose and carbohydrate overload impair cardiac autonomic modulation in healthy adults?
Absolute Event Rate: 56.1% vs 62.5%
p-value: p=<0.05
Higher fasting blood glucose, even within the normal range, is associated with impaired cardiac autonomic modulation both at fasting and after carbohydrate overload in healthy young adults.
May alter post-load autonomic balance by fasting glucose; leaves open clinical relevance pending prospective trials.
This study aimed to assess whether the blood glucose levels influence cardiac autonomic modulation under fasting and after carbohydrate overload conditions. Participants (n = 108) were separated into lower blood glucose and higher blood glucose groups, based on the median (90.5 mg·dL −1 ) of fasting glucose assessed. The SD2, SDNN, LF indices, and LF/HF increased, and HF decreased after dextrose overload compared with fasting (p < 0.05). Body mass (78.9 vs 69.7 kg), abdominal circumference (90.2 vs 82.2 cm), systolic (113 vs 108 mm Hg) and diastolic (72 vs 67 mm Hg) blood pressure were higher (p < 0.05) in the higher blood glucose group. Heart rate variability (HRV) indices (SD1: 21.0 vs 26.5; SD2: 76.8: vs 86.1; RMSSD: 28.7 vs 37.5; SDNN: 56.1 vs 62.5 ms; pNN50: 10.6 vs 18.9%, HF: 328.4 vs 506.0; LF: 982.8 vs 1259.0 ms 2 ), and the area under the curve of these indices after dextrose overload were lower in the higher blood glucose group (p < 0.05). Additionally, glycemia after dextrose overload was correlated with HRV indices (ρ = –0.216 to −0.273, p < 0.05). Individuals with higher blood glucose, even in the normality range, showed impairment in the cardiac autonomic modulation both at fasting and after carbohydrate overload. Novelty: Higher fasting blood glucose impairs cardiac autonomic modulation. Carbohydrate overload impairs cardiac autonomic modulation.
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Oliveira et al. (2020) conducted a cross-sectional in Healthy adults (n=108). Higher fasting blood glucose (> 90.5 mg/dL) vs. Lower fasting blood glucose (< 90.5 mg/dL) was evaluated on Heart rate variability (SDNN in ms) (p=<0.05). Individuals with higher fasting blood glucose (>90.5 mg/dL) demonstrated significantly lower heart rate variability indices, including SDNN (56.1 vs 62.5 ms), both at fasting and after carbohydrate overload.
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