Key result
Elevated plasma glucose is linked to reduced heart rate variability.
Why the study?
Does hyperglycemia reduce heart rate variability in a community-based population?
Population
1,919 men and women from the Framingham Offspring Study who underwent ambulatory electrocardiographic…
Comparison
Hyperglycemia vs Normal fasting glucose (<110 mg/dl, n=1,779)
Design
Cross-sectional
Authors
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Association in cross-sectional data may signal autonomic effects; leaves open causality and precludes practice change.
Cohort (n=1,919)
Does hyperglycemia reduce heart rate variability in a community-based population?
p-value: p=<0.0001
Heart rate variability is inversely associated with plasma glucose levels and is significantly reduced in individuals with diabetes and impaired fasting glucose.
Singh et al. (2000) conducted a cohort in Hyperglycemia (n=1,919). Elevated fasting plasma glucose (impaired fasting glucose or diabetes mellitus) vs. Normal fasting glucose (<110 mg/dl) was evaluated on Heart rate variability (SDNN, LF and HF power, LF/HF ratio) (p=<0.0001). Elevated plasma glucose levels were inversely associated with heart rate variability metrics, which were significantly reduced in diabetic and impaired fasting glucose subjects (p<0.0001).
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