Quantitative ultrasound parameters demonstrated steatosis grading accuracies of 61.7% and 68.3%, compared to 51.7% for conventional ultrasound and 76.7% for MRI-estimated PDFF.
Observational (n=61)
Does quantitative ultrasound improve diagnostic accuracy for predicting hepatic steatosis grade compared to conventional ultrasound in adults with NAFLD?
Quantitative ultrasound parameters may provide higher accuracy and interobserver agreement than conventional ultrasound for predicting hepatic steatosis grade in NAFLD.
Absolute Event Rate: 68.3% vs 51.7%
OBJECTIVE: The purpose of this study is to explore the diagnostic performance of two investigational quantitative ultrasound (QUS) parameters, attenuation coefficient and backscatter coefficient, in comparison with conventional ultrasound (CUS) and MRI-estimated proton density fat fraction (PDFF) for predicting histology-confirmed steatosis grade in adults with nonalcoholic fatty liver disease (NAFLD). SUBJECTS AND METHODS: In this prospectively designed pilot study, 61 adults with histology-confirmed NAFLD were enrolled from September 2012 to February 2014. Subjects underwent QUS, CUS, and MRI examinations within 100 days of clinical-care liver biopsy. QUS parameters (attenuation coefficient and backscatter coefficient) were estimated using a reference phantom technique by two analysts independently. Three-point ordinal CUS scores intended to predict steatosis grade (1, 2, or 3) were generated independently by two radiologists on the basis of QUS features. PDFF was estimated using an advanced chemical shift-based MRI technique. Using histologic examination as the reference standard, ROC analysis was performed. Optimal attenuation coefficient, backscatter coefficient, and PDFF cutoff thresholds were identified, and the accuracy of attenuation coefficient, backscatter coefficient, PDFF, and CUS to predict steatosis grade was determined. Interobserver agreement for attenuation coefficient, backscatter coefficient, and CUS was analyzed. RESULTS: CUS had 51.7% grading accuracy. The raw and cross-validated steatosis grading accuracies were 61.7% and 55.0%, respectively, for attenuation coefficient, 68.3% and 68.3% for backscatter coefficient, and 76.7% and 71.3% for MRI-estimated PDFF. Interobserver agreements were 53.3% for CUS (κ = 0.61), 90.0% for attenuation coefficient (κ = 0.87), and 71.7% for backscatter coefficient (κ = 0.82) (p < 0.0001 for all). CONCLUSION: Preliminary observations suggest that QUS parameters may be more accurate and provide higher interobserver agreement than CUS for predicting hepatic steatosis grade in patients with NAFLD.
Paige et al. (Tue,) conducted a observational in Nonalcoholic fatty liver disease (NAFLD) (n=61). Quantitative ultrasound (QUS) vs. Conventional ultrasound (CUS) and MRI-estimated PDFF was evaluated on Accuracy to predict histology-confirmed steatosis grade. Quantitative ultrasound parameters demonstrated steatosis grading accuracies of 61.7% and 68.3%, compared to 51.7% for conventional ultrasound and 76.7% for MRI-estimated PDFF.