Key result
A coarse-grained version of the Huxley model successfully recapitulated the key features of force-length behavior in activated airway smooth muscle and accounted for sustained force reductions following large stretch.
Population
Computational model of airway smooth muscle (ASM)
Design
Preclinical
Authors
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Simplifies airway smooth muscle modeling; leaves open translation to human asthma without further validation.
A simplified, coarse-grained version of the Huxley model successfully predicts the transient and sustained reductions in active force of airway smooth muscle following stretch without assuming precise cross-bridge alignment.
Jason H. T. Bates (2015) studied Airway smooth muscle mechanics. Coarse-grained Huxley model vs. Classic Huxley model was evaluated on Force-length behavior of activated airway smooth muscle. A coarse-grained version of the Huxley model successfully recapitulated the key features of force-length behavior in activated airway smooth muscle and accounted for sustained force reductions following large stretch.
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