Why the study?
Does tidal stretch amplitude affect active force, stiffness, and hysteresivity in isolated bovine tracheal smooth muscle?
Population
Isolated, maximally contracted bovine tracheal smooth muscle
Comparison
Tidal stretches imposed at 0.33 Hz with varying… vs Different amplitudes of stretch
Design
Preclinical
Authors
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Caution against extrapolating to human ventilation strategies; leaves open dynamic stretch effects on airway smooth muscle in asthma.
Does tidal stretch amplitude affect active force, stiffness, and hysteresivity in isolated bovine tracheal smooth muscle?
Tidal changes in muscle length cause an excess rate of detachment of actin-myosin interactions, suggesting airway lumenal narrowing is governed by a dynamic mechanical process rather than static equilibrium.
Fredberg et al. (1997) studied this question.
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