Population
Activated canine airway smooth muscle
Design
Preclinical
Authors
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May explain deep-inspiration failure in asthma; leaves open whether cross-bridge modulation is therapeutically relevant in humans.
Steady-state force maintenance (latch) in airway smooth muscle is a low-friction state, which may explain the inability of asthmatic patients to reverse spontaneous airways obstruction with a deep inspiration.
Fredberg et al. (1996) studied this question.
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