Key result
In stroke-prone spontaneously hypertensive rats, sacubitril/valsartan significantly reduced blood pressure and proteinuria, completely prevented stroke, and delayed organ damage progression vs valsartan.
Why the study?
Does sacubitril/valsartan reduce blood pressure and prevent target organ damage compared to valsartan in stroke-prone spontaneously hypertensive rats?
Does sacubitril/valsartan reduce blood pressure and prevent target organ damage compared to valsartan in stroke-prone spontaneously hypertensive rats?
In a hypertensive rat model, sacubitril/valsartan provided superior blood pressure reduction and protection against stroke and renal damage compared to valsartan alone.
OBJECTIVES: The combination of AT1 blocker/neutroendopeptidase neprilysin inhibition (ARNi) represents an interesting approach to reduce cardiovascular risk in hypertension. We assessed the efficacy of ARNi, compared with angiotensin II type 1 receptor blockade alone, on blood pressure (BP) and on protection from target organ damage development in the stroke-prone spontaneously hypertensive rat (SHRSP). METHODS: In high-salt fed SHRSP, we assessed plasma and tissue natriuretic peptides, urinary volume, BP and body weight over a short-term treatment (6 weeks) with either ARNi (sacubitril/valsartan 68 mg/kg per day) or valsartan (30 mg/kg per day), protection from stroke and renal damage (as documented by proteinuria) over 4 months of treatment with either sacubitril/valsartan or valsartan; the ability of either treatment to reduce progression of cerebrovascular and renal damage after 2 weeks of high-salt diet. RESULTS: Higher levels of plasma and tissue atrial natriuretic peptide, of urinary cyclic guanosine 3'5'monophosphate and urine volumes, along with lower BP levels, were found upon sacubitril/valsartan as compared with valsartan over the short-term treatment. Sacubitril/valsartan caused a significant reduction of both BP and proteinuria levels and complete prevention of stroke over the long-term treatment. Once organ damage was established, a significant delay of its progression was observed with sacubitril/valsartan. CONCLUSION: The dual angiotensin II type 1 receptor/neutroendopeptidase inhibition significantly increased atrial natriuretic peptide level and reduced BP. Complete prevention of stroke was achieved in this model. The ability of sacubitril/valsartan to reduce organ damage progression was superior to that of valsartan alone. ARNi may represent a highly effective therapeutic agent to protect from target organ damage development in hypertension.
No takes yet. Share an insight, caveat, or question.
Rubattu et al. (2018) studied Hypertension (stroke-prone spontaneously hypertensive rat model). Sacubitril/valsartan vs. Valsartan (30 mg/kg per day) was evaluated on Blood pressure, protection from stroke and renal damage, and progression of cerebrovascular and renal damage. In stroke-prone spontaneously hypertensive rats, sacubitril/valsartan significantly reduced blood pressure and proteinuria, completely prevented stroke, and delayed organ damage progression vs valsartan.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: