Why the study?
Does depletion of phosphocreatine and ATP alter the forward flux of creatine kinase in the normoxic rat heart?
Population
Isovolumic acetate-perfused rat heart (acute normoxic model)
Comparison
Prior perfusion with 2 deoxy-D-glucose in the… vs Control (normal PCr and ATP concentrations)
Design
Preclinical
Authors
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Challenges metabolite-only models of CK flux in normoxic rat heart; leaves open compartmentation effects in human disease.
Does depletion of phosphocreatine and ATP alter the forward flux of creatine kinase in the normoxic rat heart?
In a normoxic rat heart model, creatine kinase flux cannot be fully predicted by metabolite concentrations alone, suggesting metabolite and isozyme compartmentation.
Степанов et al. (1997) studied this question.
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