Sleep-Time Blood Pressure and the Prognostic Value of Isolated-Office and Masked Hypertension
Key result
Out-of-office hypertension defined by asleep blood pressure was associated with higher cardiovascular risk than normotension and isolated-office hypertension (P<0.001).
Why the study?
Does sleep-time blood pressure better predict cardiovascular risk compared to awake or 24-hour blood pressure?
Population
3,344 subjects (1,718 men, 1,626 women), mean age 52.6 ± 14.5 years.
Comparison
Sleep-time blood pressure measurement via… vs Awake or 24-hour blood pressure mean
Design
Cohort
Follow-up
median 5.6-years
Authors
Discussion
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Implication
May refine CV risk stratification via ambulatory monitoring; leaves open whether sleep-time BP targeting improves outcomes in trials.
Study Design
Type
Cohort (n=3,344)
Structured PICO
Does sleep-time blood pressure better predict cardiovascular risk compared to awake or 24-hour blood pressure?
P
Population
3,344 subjects (mean age 52.6 years) followed for a median of 5.6 years to evaluate the prognostic value of sleep-time blood pressure.
E
Exposure
Sleep-time blood pressure measurement via 48-hour ambulatory monitoring
C
Comparator
Awake or 24-hour blood pressure mean
O
Outcome
Cardiovascular risk/outcome
Main Result
p-value: p=<0.001
Sleep-time blood pressure determined by ambulatory monitoring is a superior independent predictor of cardiovascular risk compared to awake or 24-hour measurements and prevents misclassification of hypertension phenotypes.
Cite This Study
Hermida et al. (2011) conducted a cohort in Hypertension (n=3,344). Elevated sleep-time blood pressure vs. Normotension and isolated-office hypertension was evaluated on Cardiovascular risk (p=<0.001). Out-of-office hypertension defined by asleep blood pressure was associated with higher cardiovascular risk than normotension and isolated-office hypertension (P<0.001).