Population
In vitro biochemical model using heavy meromyosin (HMM) with 85% intact light chain 2 and regulated actin
Comparison
Presence of Ca2+ vs Absence of Ca2+
Design
Preclinical
Authors
Loading...
Modest Ca2+-dependent HMM binding increase; extends models showing troponin-tropomyosin regulation is primarily kinetic in striated muscle.
Troponin-tropomyosin primarily regulates acto-HMM ATPase activity by inhibiting a kinetic step, while also slightly modulating cross-bridge binding to actin.
Chalovich et al. (1986) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: