Population
Heavy meromyosin prepared from vertebrate striated muscle myosin, and regulated actin
Comparison
Presence or absence of calcium, removal/addition… vs Respective control conditions
Design
Preclinical
Authors
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Establishes molecular requirements for Ca2+-sensitive actomyosin binding in vitro; leaves open relevance to cardiac muscle physiology.
The calcium-sensitive binding of heavy meromyosin to regulated actin requires both the head-tail junction and the N-terminal part of light chain 2 to be intact.
Wagner et al. (1983) studied this question.
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