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January 1, 1969The Journal of Cell BiologyOpen Access

The Effect of Various Protein Fractions on Z- And M-Line Reconstitution

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Population

Thin, glycerinated bundles of rabbit psoas muscle

Design

Preclinical

Authors

MSMarvin H. StromerIowa State UniversityDHD.J. HartshorneUniversity of ArizonaHMHelmut MuellerOak Ridge National Laboratory

Discussion

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Overview

No immediate clinical implications; leaves open validation of Z-line protein candidates in mammalian models.

Structured PICO

P
Population
Thin, glycerinated bundles of rabbit psoas muscle
I
Intervention
Interaction with dilute myofibrillar extract or fractions obtained at 40% ammonium sulfate saturation from myofibrillar extract or Bailey extract of natural actomyosin
O
Outcome
Reconstitution of Z lines and M linessurrogate

This basic science study suggests that alpha-actinin, rather than tropomyosin or troponin alone, is a likely major protein component of the Z line in muscle fibers.

Cite This Study

Stromer et al. (1969) studied this question.

synapsesocial.com/papers/6a75204501b447f0dadc036dhttps://doi.org/10.1083/jcb.40.1.167
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1THE ULTRASTRUCTURE OF THE M LINE IN SKELETAL MUSCLE1968 · 133 citations
  2. 2Tropomyosin Paracrystals Formed by Divalent Cations1966 · 125 citations
  3. 3Some observations on the localization of myosin, actin and tropomyosin in the rabbit myofibril1958 · 81 citations
  4. 4REMOVAL AND RECONSTITUTION OF Z-LINE MATERIAL IN A STRIATED MUSCLE1967 · 50 citations
  5. 5THE ULTRASTRUCTURE OF THE Z DISC IN SKELETAL MUSCLE1962 · 219 citations