Lung-Residing Myeloid-derived Suppressors Display Dual Functionality in Murine Pulmonary Tuberculosis

Julia K. Knaul; Sabine Jörg; Dagmar Oberbeck‐Mueller; Ellen Heinemann; Lisa Scheuermann; Volker Brinkmann; Hans‐Joachim Mollenkopf; Vladimir Yeremeev; Stefan H. E. Kaufmann; Anca Dorhoi

doi:10.1164/rccm.201405-0828oc

October 2, 2014American Journal of Respiratory and Critical Care Medicine

Lung-Residing Myeloid-derived Suppressors Display Dual Functionality in Murine Pulmonary Tuberculosis

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Key Points

To examine the presence, immunologic functions, and direct interactions of myeloid-derived suppressor cells (MDSCs) with Mycobacterium tuberculosis during pulmonary tuberculosis.
Assessed MDSC phagocytosis, cytokine production, and suppressive capacity following direct exposure to Mycobacterium tuberculosis in cell-based assays.
Characterized MDSC accumulation in the lungs of disease-resistant and disease-susceptible mouse models of pulmonary tuberculosis.
Evaluated the impact of targeted MDSC depletion on tuberculosis outcomes in vivo.
MDSCs readily engulfed Mycobacterium tuberculosis and secreted IL-6, IL-1α, and IL-10 while preserving their T-cell suppressive capacity.
Extensive MDSC accumulation in infected lungs correlated with increased cell-surface expression of IL-4Rα and increased tuberculosis mortality.
Targeted depletion of MDSCs reduced disease severity and improved survival in murine pulmonary tuberculosis.

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Implication

Experimental animal study reveals dual immune regulatory roles of myeloid-derived suppressor cells in pulmonary tuberculosis, suggesting novel targets for host-directed therapy.

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Knaul et al. (2014) studied this question.

synapsesocial.com/papers/6a7525441078cf7de2b1fade https://doi.org/10.1164/rccm.201405-0828oc

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Lung-Residing Myeloid-derived Suppressors Display Dual Functionality in Murine Pulmonary Tuberculosis

Key Points

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Discussion

Cite This Study

Lung-Residing Myeloid-derived Suppressors Display Dual Functionality in Murine Pulmonary Tuberculosis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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