Why the study?
The 2019 ESC guidelines introduced a revised definition of high-risk PE encompassing cardiac arrest, obstructive shock, and persistent hypotension, but its prognostic implications required investigation.
Does the 2019 ESC definition of high-risk PE accurately stratify subgroups at different risk of in-hospital adverse outcomes and mortality?
Population
784 consecutive PE patients enrolled in a single-centre registry
Comparison
High-risk PE clinical presentations vs intermediate-high-risk PE
Design
Prospective single-centre registry cohort study
Follow-up
In-hospital
Authors
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Refined 2019 ESC high-risk PE definition aids in-hospital prognostication; leaves open impact on management decisions.
Does the 2019 ESC definition of high-risk PE accurately stratify subgroups at different risk of in-hospital adverse outcomes and mortality?
The 2019 ESC definition of high-risk PE identifies subgroups with varying mortality risks, and an optimized venous lactate cut-off of 3.8 mmol/L improves risk stratification between obstructive shock and persistent hypotension.
Ebner et al. (2021) studied this question.
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