Muchdiscussion centres onthe exactnomenclature ofthese conditions, andno attempt ismadeheretoelucidate this matter. Gall andMallory (1942) discuss theproblems involved, andsuggest a cytological basis forsubdivision; Custer andBernhard (1948) pointoutthatthe cellular structure oflymphatic tumours isextremely labile, andthattransition fromoneapparently distinct typetoanother isfrequently seen, sothat anabsolute cytological diagnosis bybiopsy maybe verydifficult. Fromthedescriptive standpoint, withtheexception perhaps ofHodgkin's disease, these conditions arerelegated tosmallsections oftheaverage paediatric textbook, emphasis generally being placed onenlargement oflymphnodesinthesymptomatology. Arey(1949) doesnotdiscuss Hodgkin's disease orlymphosarcoma, stating thattheyhave their counterparts inadult life. Dargeon(1947) states thatthephysical signs andsymptoms of lymphosarcoma will depend ontheanatomical site of theaffected structures, andsaysthatthenasopharynx, thetonsil andthecervical, oranyother groupofnodes, maybeinvolved. Inalater study (1953), however, hedescribes morespecific cases, andemphasizes thedifficulty ofdiagnosis and management. Material Thecases aredrawnfromthepractice ofthe University hospitals oftheUniversity ofWisconsin. Inall12casesthediagnosis wasestablished by biopsy, atnecropsy, orbybothmeans. Thecytological diagnosis wasvariously stated tobelymphoblastoma, lymphosarcoma orreticulum-cell sarcoma, eachthusbeing included inthelymphomata as described byGallandMallory, orrepresented in thelymphoblastomata ofCuster andBernhard. CaseHistories Case1.
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George M. Maxwell (1954) studied this question.
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